The vast majority of studies on weight loss, energy enhancement, and organ protection have used doses of resveratrol substantially higher than those obtainable from foods. This is not to say that food sources of resveratrol and other polyphenols are not important.
Sources of resveratrol include concentrated juice extracts. These include products like the Australian extract and Naturex’s Powergrape, both promising products but not yet available. Other juice products, including fruit juices like Noni, XanGo, and others that tout the health benefits of polyphenols and antioxidants, are available commercially Nonalcoholic red grape juice and other fruit juices also can provide substantial amounts of polyphenols, but currently, only dietary supplements offer the doses of resveratrol and other polyphenols used in selected animal and human studies.
The products we have most considered include Resveratrol Select , those made by Resveratrol Partners (wwwlongevinex.com), Biotivia (www.biotivia.com). and RevGenetics (www.revegenetics.com). The sources ofthese products, their manufacturing procedures, their costs, and other Information can be found on their respective websites. Because of the tremendous interest in this subject, there is little doubt the range of products available will be exploding.
Many resveratrol products and concentrated polyphenol products, not quite yet commercially available, will soon be on the market in both capsule and drink form. The key factor in many products· will be not just the amount of resveratrol or other polyphenols, but that human clinical trials are conducted on them. The optimal dosage of any of these dietary supplements or polyphenol concentrates cannot yet be confirmed based on the limited human data.
But from hundreds of laboratory studies, we believe that for a young, healthy, normally active individual, a dose in the range of 100 to 500 milligrams a day is reasonable and safe. For those over 40; a dose closer to 500 milligrams a day might be more appropriate. For athletes desiring enhanced energy and mitochondrial activity, even higher doses might be considered. I personally take 250 to 500 milligrams of resveratrol per day, as well as 400 milligrams of a mixed polyphenol supplement. As noted earlier, according to an unscientific survey of those who indicated they were invested in Sirtris Pharmaceuticals, 20 percent of these individuals take more than 100,000 milligrams per day of resveratrol. No source of this product was indicated in the survey
Genes and Lifespan The factors that can determine longevity are partly due to your genetic makeup. But lifestyle choices, such as nutrition, exercise, and smoking-which are controlled by you-are the more important factors.
A list of five essentials: healthy diet, exercise, mental challenge, novelty in our lives, and meditation/spirituality for emotional balance. The second approach involves our genes: either we fall into that group fortunate enough to be born with good genes for longevity, or we activate such genes through healthy living and genetically bioactive compounds like those found in plants (polyphenols).